Gut-on-chip (GOC) platforms are microfluidic devices with micro-chambers and channels to support and control media volumes and flow through a living cell culture generally seeded on membranes that create 2 chambers (lower and upper). This technology mimics the physiological architecture and function as well as the pathological states of human epithelial organs. Several models reproducing human GOC have underlined their potential value as for disease and drug screening modelling.