Background: Renal artery denervation (RDN) has provided incremental atrial fibrillation (AF) suppression after pulmonary vein isolation (PVI) in patients with AF in the setting of drug-resistant hypertension, but the antiarrhythmic mechanism by which RND functions is unknown. Objectives. The aim of this study was to assess the relationship between blood pressure changes after RDN when added to PVI and AF recurrences/AF burden detected by implantable loop recorder (ILR) during one-year follow-up.Methods: All patients from two randomized studies (NCT01117025 and NCT01897545) with a history of symptomatic paroxysmal (P) AF and/or persistent (Pers) AF and resistant hypertension (≥ 3 antihypertensive drugs) who underwent PVI or PVI with RDN, and ILR implantation, were eligible for this study. Patients underwent PVI only (n= 37) or PVI with RDN (n= 39) and were followed-up for one...