Today ultra-flexible electronic devices can be successfully embedded in smart clothes, integrated in transparent displays, hidden in tubular structures to increase the numbers of sensors in an urban space or in a specific environment, thus enhancing the interaction of a person and maximizing the shared amount of available information. Coupling this technology with nanostructures based sensing devices is a further step to revolutionize the idea of distributed smart objects. Polysilicon based materials on plastic is a mature technology to fabricate electronic read-out circuits suitable to manage and control the signals coming from sensors of different nature, conceiving new applications and wearable solutions. Moreover, the possibility of directly integrating active devices together with sensors reduces issues related to signal to noise ratio, providing a local preamplification.