We recently introduced a reliable fabrication process enabling the integration of dielectric and metallic nanostructures directly on the tip of optical fibers, involving conventional deposition and nanopatterning techniques suitably adapted to directly operate on the fiber tip1. By using this approach, we also demonstrated a first technological platform based on the integration, on the optical fiber tip, of 2D hybrid metallo-dielectric nanostructures supporting localized surface plasmon resonances, that can be efficiently used for label free chemical and biological sensing. In this contribution we want to emphasize the versatility of the proposed technological platform. In particular, we demonstrate how by acting on the numerous degrees of freedom it provides, we are able to improve the performances of our nanoprobes for label-free chemical and biological sensing applications. Finally, the possibility to create novel advanced …