A solid phase oligonucleotide (ON) synthesis on porous silicon (PSi) chip is presented. The prepared Si- OH surface were analyzed by FT-IR and the OH functions were quantified by reaction with 3′- phosphoramidite nucleotide building block. Short ONs were synthesized on the chip surface and the coupling yields evaluated.
Oxford University Press
1 Sep 2008
Volume: 52 Issue: 1 Pages: 721-722
Nucleic Acids Symposium Series