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Type: 
Journal
Description: 
One of the most important goals in the fields of biology and medicine is the possibility to dispose of efficient tools for the characterization of the extraordinary complexity of ligand-receptor interactions. To approach this theme, we explored the use of crystalline silicon (cSi) technology for the realization of a biotechnological device in which the ligand-receptor interactions are revealed by means of optical measurements. Here, we describe a chemical procedure for the functionalization of microwell etched on silicon wafers, and the subsequent anchoring of biological molecules like an antibody anti-A20 murine lymphoma cell line. The optical analysis of the interaction on the biochips between the bound biomolecule and their corresponding ligand indicated that the functionalized cSi is suitable for this application.
Publisher: 
Hindawi
Publication date: 
1 Jan 2012
Authors: 

Annalisa Lamberti, Carmen Sanges, Nunzia Migliaccio, Luca De Stefano, Ilaria Rea, Emanuele Orabona, Giuseppe Scala, Ivo Rendina, Paolo Arcari

Biblio References: 
Volume: 2012
Origin: 
Journal of Atomic and Molecular Physics