The realization of a novel microfluidic device for inducing cell rotation is reported. It exploits the hydrodynamic forces acting on cells moving in a flow characterized by a parabolic velocity profile. The device operation was tested on yeast cells, since they have an asymmetrical shape due to a bud formation during the duplication phase. Image processing analysis of the experimental data allowed to precisely evaluate the cell angular orientation and rotation rate.
20 May 2015
2015 International Conference on BioPhotonics (BioPhotonics)