We have recently demonstrated a valuable fabrication path for the integration and patterning of functional materials at micro and nano-scale onto optical fibers, posing the basis for a new and emerging technological vision named “Lab on Fiber”. This process has been validated through the realization, directly onto the fiber tip, of 2D metallo-dielectric nano-crystals, supporting local surface plasmon resonances (LSPRs). In this work, we demonstrate numerically and experimentally, how it is possible to obtain polarization sensitive devices, by breaking the circular crystal symmetry and /or the lattice periodicity of our platform.