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Single-wall carbon nanotubes (SWCNTs) could be promising delivery vehicles for cancer therapy. These carriers are generally introduced intravenously, however, little is known of their interactions with endothelial cells, the cells lining vessels and mediating clearance of nanoparticles. Here we show that SWCNTs of 1 to 5 μm in length, both “pristine” and functionalized by oxidation, had limited toxicity for endothelial cells in vitro as determined by growth, migration morphogenesis, and survival assays. Endothelial cells transiently took up SWCNTs, and several lines of data indicated that they were associated with an enhanced acidic vesicle compartment within the endothelial cells. Our findings of SWCNT interactions with endothelial cells suggest these may be optimal vehicles for targeting the vasculature and potential carriers of anti-angiogenic drugs. The implications on their biological activity must be taken into …
Publication date: 
1 Apr 2010

Adriana Albini, Valentina Mussi, Alessandro Parodi, Agostina Ventura, Elisa Principi, Sara Tegami, Massimiliano Rocchia, Enrico Francheschi, Ilaria Sogno, Rosaria Cammarota, Giovanna Finzi, Fausto Sessa, Douglas McClain Noonan, Ugo Valbusa

Biblio References: 
Volume: 6 Issue: 2 Pages: 277-288
Nanomedicine: Nanotechnology, Biology and Medicine