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We evaluated the integrity of the cortical network in the Fmr1 knockout mouse model of fragile X syndrome (FXS) by recording micro-electrocorticogram (ECoG) activity and measuring functional connectivity, alongside the degree of clustering (modularity) and integration capacity (path length). We found that functional connectivity is increased at both the short- and long-range levels, especially in prefrontal areas in the FXS model. This correlates with a decrement in the degree of cortical network clustering, together with an anomalously high information exchange capacity at high-frequency oscillatory bands. We conclude that the cognitive deficits manifested in FXS could be associated with the state of over-synchronization of the cortical network, which is more evident at high-frequency oscillatory bands and at frontal areas of the brain.
Springer, Singapore
Publication date: 
1 Jan 2018

Miguel Dasilva, Alvaro Navarro-Guzman, Luca Maiolo, Andres Ozaita, Maria V Sanchez-Vives

Biblio References: 
Pages: 255-261
Advances in Cognitive Neurodynamics (VI)