Large-area nanostructured transducer for absorption opto-plasmonic measurements in the ultraviolet visible UV-VIS spectral range have been realized by colloidal lithography. The design and simulation performed guarantee the optical behaviour of the nanostructured transducers. Morphological characterization by AFM microscopy evidences the nanodome structure of the object realized in array configuration. A microfluidic device was optimized to perform measurements in real time. Qualitative evaluation of the peroxides’ and bisphenols’ concentration in extra virgin olive oil (EVOO) have been obtained by following the variation in the plasmonic resonance monitoring of a suitable array nanodome structure deposited onto a glass substrate. Comparison of the obtained results with laboratory-standard methodologies gives us guaranteed support of the potential of the realized technology. View Full-Text