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Evidence suggests a beneficial role of the Mediterranean Diet (MedDiet) on health-related quality of life (HRQoL) in healthy subjects. HRQoL is relevant in cancer therapy and disease outcomes, therefore we investigated the association between adherence to the MedDiet and HRQoL in breast cancer survivors participating in the multicentre trial DEDiCa. Diet and HRQoL were assessed at baseline in a subgroup of 309 women enrolled within 12 months of breast cancer diagnosis without metastasis (stages I-III, mean age 52±1 yrs, BMI 27±7 kg/m2). The 14-item PREDIMED questionnaire was used to analyse adherence to the MedDiet. HRQoL was assessed with three validated questionnaires measuring physical, mental, emotional and social factors: EQ-5D-3L, EORTC QLQ-C30 and EORTC QLQ-BR23. Analysis of variance (ANOVA) and multivariate analyses were performed to assess the possible role of the MedDiet on HRQoL. Patients with higher adherence to MedDiet (PREDIMED score >7) showed significantly higher scores for physical functioning (p = 0.02) and lower scores on the symptomatic pain scale (p = 0.04) assessed by the EORTC QLQ-C30 questionnaire compared to patients with a lower adherence to MedDiet (PREDIMED score ≤7). Higher scores from the EQ-5D-3L indicating higher well-being were observed mainly in participants with higher MedDiet adherence (p = 0.05). In adjusted multivariate analyses significant positive associations were found between MedDiet, physical functioning (p = 0.001) and EQ 5D-3L score (p = 0.003) while inverse associations were found with pain and insomnia symptoms (p = 0.005 and p = 0 …
Public Library of Science
Publication date: 
8 Oct 2020

Giuseppe Porciello, Concetta Montagnese, Anna Crispo, Maria Grimaldi, Massimo Libra, Sara Vitale, Elvira Palumbo, Rosa Pica, Ilaria Calabrese, Serena Cubisino, Luca Falzone, Luigina Poletto, Valentina Martinuzzo, Melania Prete, Nadia Esindi, Guglielmo Thomas, Daniela Cianniello, Monica Pinto, Michelino De Laurentiis, Carmen Pacilio, Massimo Rinaldo, Massimiliano D’Aiuto, Diego Serraino, Samuele Massarut, Chiara Evangelista, Agostino Steffan, Francesca Catalano, Giuseppe L Banna, Giuseppa Scandurra, Francesco Ferraù, Rosalba Rossello, Giovanna Antonelli, Gennaro Guerra, Amalia Farina, Francesco Messina, Gabriele Riccardi, Davide Gatti, David JA Jenkins, Anita Minopoli, Bruna Grilli, Ernesta Cavalcanti, Egidio Celentano, Gerardo Botti, Maurizio Montella, Livia SA Augustin

Biblio References: 
Volume: 15 Issue: 10 Pages: e0239803
PloS one