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Lanthanide-doped nanoparticles, featuring sharp emission peaks with narrow bandwidth, exhibit high downconversion luminescence intensity, making them highly valuable in the fields of bioimaging and drug delivery. High-crystallinity Y2O3 nanoparticles (NPs) doped with Er3+ ions were functionalized by using a pegylation procedure to confer water solubility and biocompatibility. The NPs were thoroughly characterized using transmission electron microscopy (TEM), inductively coupled plasma mass spectrometry (ICP-MS), and photoluminescence measurements. The pegylated nanoparticles were studied both from a toxicological perspective and to demonstrate their internalization within HCT-116 cancer cells. Cell viability tests allowed for the identification of the “optimal” concentration, which yields a detectable fluorescence signal without being toxic to the cells. The internalization process was investigated …
American Chemical Society
Publication date: 
5 Oct 2023

Regina Maria Chiechio, Angela Caponnetto, Rosalia Battaglia, Carmen Ferrara, Ester Butera, Paolo Musumeci, Riccardo Reitano, Francesco Ruffino, Giuseppe Maccarrone, Cinzia Di Pietro, Valérie Marchi, Luca Lanzanò, Giovanni Arena, Alfina Grasso, Chiara Copat, Margherita Ferrante, Annalinda Contino

Biblio References: 
ACS Applied Nano Materials