Nanostructured photoluminescent materials are optimal transducers for optical biosensors due to their capacity to convert molecular interactions in light signals without contamination or deterioration of the samples. In recent years, nanostructured biosensors with low cost and readily available properties have been developed for such applications as therapeutics, diagnostic and environmental. Zinc oxide nanowires (ZnO NWs) is material with unique properties and due to these they were widely studied in many fields as electronics, optics, and photonics. ZnO NWs can be either grown independently or deposited on solid support, such as glass, gold substrates and crystalline silicon. Vertical aligned ZnO forest on a substrate shows specific advantages in photonic device fabrication. ZnO NWs are typically synthesized by such techniques classified as vapour phase and solution phase synthesis. In particular …