Type:
Journal
Description:
Rapid screening tests in medical diagnostic and environmental analysis are often based on oligonucleotide biochips. In this paper, we studied the stability of functionalized mesoporous silicon supports in the solid-phase synthesis of oligonucleotides, exploiting several chemical procedures. A 19-mer mixed sequence has been successfully synthesized on aminosilane-modified porous silicon photonic structures. The process and the materials have been characterized by optical reflectivity, atomic force microscopy and high-performance liquid chromatography.
Publisher:
SpringerOpen
Publication date:
1 Dec 2014
Biblio References:
Volume: 9 Issue: 1 Pages: 1-9
Origin:
Nanoscale research letters