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PurposeActivated platelet gel (PG) derived from adult peripheral blood (APB) has been extensively used for topical therapy of various clinical conditions. Conversely, few observations on PG from umbilical cord blood (CB) have been reported so far. Although PG preparations are known to contain a high concentration of a large number of biological factors involved in inflammation and tissue repair, their comprehensive characterization is still missing. The innovative goal of our research was to use proteomics technologies in order to profile biologically active components in these blood derivatives.Experimental designSupernatants recovered from three independent APB and CB‐derived PGs, prepared using batroxobin, were enriched for low‐abundance proteins with ProteoMiner and subsequently analyzed by GeLC‐MS/MS.ResultsThe 751 and 760 proteins were identified in the APB and CB‐derived PG …
Publication date: 
1 Aug 2016

Valentina Longo, Paolo Rebulla, Simonetta Pupella, Lello Zolla, Sara Rinalducci

Biblio References: 
Volume: 10 Issue: 8 Pages: 870-882
PROTEOMICS–Clinical Applications