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Obtaining DNA nanostructures with potential applications in drug discovery, diagnostics, and electronics in a simple and affordable way represents one of the hottest topics in nanotechnological and medical sciences. Herein, we report a novel strategy to obtain structurally homogeneous DNA G‐wire nanostructures of known length, starting from the short unmodified G‐rich oligonucleotide d(5′‐CGGT‐3′–3′‐GGC‐5′) (1) incorporating a 3’–3′ inversion of polarity site. The reported approach allowed us to obtain long G‐wire assemblies through 5′–5′ π–π stacking interactions in between the tetramolecular G‐quadruplex building blocks that form when 1 is annealed in the presence of potassium ions. Our results expand the repertoire of synthetic methodologies to obtain new tailored DNA G‐wire nanostructures.
Publication date: 
1 Aug 2017

Giorgia Oliviero, Stefano D'Errico, Brunella Pinto, Fabrizia Nici, Principia Dardano, Ilaria Rea, Luca De Stefano, Luciano Mayol, Gennaro Piccialli, Nicola Borbone

Biblio References: 
Volume: 6 Issue: 4 Pages: 599-605