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A novel optical label-free bio-sensing platform based on a new class of resonances supported in a photonic crystal metasurface is reported herein. Molecular binding is detected as a shift in the resonant wavelength of the bound states in the continuum of radiation modes. The new configuration is applied to the recognition of the interaction between protein p53 and its protein regulatory partner murine double minute 2 (MDM2). A detection limit of 66 nM for the protein p53 is found. The device provides an excellent interrogation stability and loss-free operation, requires minimal optical interrogation equipment and can be easily optimized to work in a wide wavelength range. View Full-Text
Multidisciplinary Digital Publishing Institute
Publication date: 
1 Apr 2018

Silvia Romano, Annalisa Lamberti, Mariorosario Masullo, Erika Penzo, Stefano Cabrini, Ivo Rendina, Vito Mocella

Biblio References: 
Volume: 11 Issue: 4 Pages: 526