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Type: 
Journal
Description: 
Biodegradable polymer microneedles are recognized as a valuable route for transdermal drug delivery as well as for cutaneous treatments. According to the industrial needs, the present trend is to fabricate microneedles through stamp-less techniques. Electro-drawing has been recently proposed as an alternative fast and mild temperature strategy to the stamp based techniques for the fabrication of biodegradable polymer microneedles. However, previously presented electro-drawn microneedles were fabricated by a point-like thermal stimulation, thus, they could not be electro-drawn in parallel and displayed a pedestal at their basis. Here, we present a novel electro-drawing set up and strategy to parallelize the process and to avoid the pedestal at the microneedle basis. The new set-up is based on titanium micro-heaters integrated onto the pyroelectric substrate which is the electric field generator enabling the …
Publisher: 
Elsevier
Publication date: 
1 Feb 2018
Authors: 

F Ruggiero, R Vecchione, S Bhowmick, G Coppola, S Coppola, E Esposito, V Lettera, P Ferraro, PA Netti

Biblio References: 
Volume: 255 Pages: 1553-1560
Origin: 
Sensors and Actuators B: Chemical