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Graphene and graphene substrates display properties that have a huge potential as material interface for device and biomedical tools targeting the modulation or recovery of brain functionality. However, to be considered a reliable neural interface, graphene derived substrates should properly interact with astrocytes, favoring their growth and avoiding gliotic adverse reaction. Indeed, astrocytes are the most numerous cells in the human brain and they have crucial physiological role to maintain its homeostasis and to modulate synaptic transmission. In this work, we describe a new strategy based on the chemical modification of GO with a synthetic phospholipid (PL) to improve interaction of graphene oxide (GO) with brain astroglial cells. The PL moieties were grafted on GO sheets through polymeric brushes obtained by atom-transfer radical-polymerization (ATRP) between acryloyl-modified PL …
Royal Society of Chemistry
Publication date: 
1 Jan 2018

Manuela Melucci, Ana Borrachero, Emanuele Treossi, Alessandra Scida, Emanuela Saracino, Meganne Christian, Vittorio Morandi, Giulia Tuci, Giuliano Giambastiani, L Ottaviano, Francesco Perrozzi, Valentina Benfenati, Vincenzo Palermo

Biblio References: 
Journal of Materials Chemistry B