State-of-the-art fabrication and characterization techniques are nowadays able to experimentally control light–matter interaction at sub-nanometer scales. Thus, theoretical schemes able to overcome the limits of the classical vision and to fully take into account quantum mechanical effects are needed. In this work, we propose time-dependent density functional tight-binding (TD-DFTB) as a new workhorse for computational quantum plasmonics. DFTB has been demonstrated to be an efficient scheme for describing the structural, electronic, and optical properties of different biomolecules and carbon-based nanosystems. We report here on the absorption spectra of silver tetrahedral closed-shell Agn clusters within the framework of TD-DFTB and on their comparison with the reference ones, obtained within the first-principles time-dependent density functional theory (TD-DFT) scheme. It is found out that, under an …