Type:
Journal
Description:
Microparticles of colloidal CaCO3 cores coated with Layer-by-Layer (LbL) self-assembled oppositely charged biocompatible (PSS\PAH) or biodegradable (DXS\PRM) polyelectrolytes and hollow capsules, obtained after removal of carbonate cores by EDTA, were fabricated and characterised by z-Potential, Scanning Electron microscopy (SEM) and Scanning Force Microscopy (SFM).Fluorescently-labelled polymer layers coated onto carbonate cores were employed for evaluating cell uptake efficiency and confocal laser scanning microscopy (CLSM) has been used to confirm pre-formed biodegradable multilayers dissolution.The internalisation efficiency and cytotoxicity of polymer capsules were studied in three different adherent cells (e.g.HeLa human cervice cancer), MCF-7 (human breast cancer) and B104 (murine neuroblastoma).The cyto-viability was preserved, indicating the cell safety and tolerability of these …
Publisher:
中国医药生物技术协会
Publication date:
1 Jun 2009
Biblio References:
Pages: 542-542
Origin:
BIT ‘s2nd Annual World Cancer Congess-2009 (2009 第二届癌症大会)