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Graphene and graphene substrates display huge potential as material interfaces for devices and biomedical tools targeting the modulation or recovery of brain functionality. However, to be considered reliable neural interfaces, graphene-derived substrates should properly interact with astrocytes, favoring their growth and avoiding adverse gliotic reactions. Indeed, astrocytes are the most abundant cells in the human brain and they have a crucial physiological role to maintain its homeostasis and modulate synaptic transmission. In this work, we describe a new strategy based on the chemical modification of graphene oxide (GO) with a synthetic phospholipid (PL) to improve interaction of GO with brain astroglial cells. The PL moieties were grafted on GO sheets through polymeric brushes obtained by atom-transfer radical-polymerization (ATRP) between acryloyl-modified PL and GO nanosheets modified with a …
Royal Society of Chemistry
Publication date: 
1 Jan 2018

Margherita Durso, Ana Isabel Borrachero-Conejo, Cristian Bettini, Emanuele Treossi, Alessandra Scidà, Emanuela Saracino, Massimo Gazzano, Meganne Christian, Vittorio Morandi, G Tuci, G Giambastiani, L Ottaviano, F Perrozzi, Valentina Benfenati, Manuela Melucci, Vincenzo Palermo

Biblio References: 
Volume: 6 Issue: 33 Pages: 5335-5342
Journal of Materials Chemistry B