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The aim of this study was to evaluate the toxicity of titanium dioxide nanoparticles (TiO2NPs) by short‐term toxicity tests in Apis mellifera, considered an excellent bioindicator organism mainly due to its sensitivity. Bees have been exposed to several concentrations of TiO2NPs (1 × 10−3, 1 × 10−4, 1 × 10−5, 1 × 10−6 mg/10 ml) for 10 days. Morphostructural and histological assays were done on gut and honey sac. The research of exposure biomarkers like metallothioneins 1 (MT1) and Heat Shock Protein 70 (HSP70) was performed to verify if a detoxification mechanism has been activated in the exposed animals. No histological alteration on the epithelium of the gut and honey sac were observed in exposed samples. A significant positivity for anti‐MT1 antibody was observed only in the honey sac cells. A weak positivity for HSP70 was observed in both structures analyzed. In several studies have shown the …
John Wiley & Sons, Inc.
Publication date: 
1 Apr 2020

Giulia Ferrara, Antonio Salvaggio, Roberta Pecoraro, Elena Maria Scalisi, Andrea Maria Presti, Giuliana Impellizzeri, Maria Violetta Brundo

Biblio References: 
Volume: 83 Issue: 4 Pages: 332-337
Microscopy Research and Technique