Hybrid structures composed of layered one-dimensional (1D) and two-dimensional (2D) materials opened new perspectives and opportunities through the build-up of hetero-junctions with versatile layered structures and led to fascinating fundamental phenomena and advanced devices. We succeeded in depositing by magnetron sputtering vertically aligned 1D ZnO nanorods on 2D MoS 2 flakes obtained by exfoliation, preserving the structure of the 2D materials. The photoluminescence (PL) optical properties of the hybrid structure were assessed towards developing a contactless optical chemical sensor.