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Hyperglycemia and hyperinsulinemia may play a role in breast carcinogenesis and prediabetes and diabetes have been associated with increased breast cancer (BC) risk. However, whether BC molecular subtypes may modify these associations is less clear. We therefore investigated these associations in all cases and by BC molecular subtypes among women living in Southern Italy. Cases were 557 patients with non‐metastatic incident BC and controls were 592 outpatients enrolled during the same period as cases and in the same hospital for skin‐related non‐malignant conditions. Adjusted multivariate logistic regression models were built to assess the risks of developing BC in the presence of prediabetes or diabetes. The analyses were repeated by strata of BC molecular subtypes: Luminal A, Luminal B, HER2+, and Triple Negative (TN). Prediabetes and diabetes were significantly associated with higher BC …
Publication date: 
1 May 2017

A Crispo, LSA Augustin, M Grimaldi, Flavia Nocerino, A Giudice, E Cavalcanti, M Di Bonito, G Botti, M De Laurentiis, M Rinaldo, E Esposito, G Riccardi, A Amore, M Libra, G Ciliberto, DJA Jenkins, M Montella

Biblio References: 
Volume: 232 Issue: 5 Pages: 1144-1150
Journal of cellular physiology