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According to their high electron density and ultrasmall size, gold nanoclusters (AuNCs) have unique luminescence and photoelectrochemical properties that make them very attractive for various biomedical fields. These applications require a clear understanding of their interaction with biological membranes. Here we demonstrate the ability of the AuNCs as markers for lipidic bilayer structures such as synthetic liposomes and biological extracellular vesicles (EVs). The AuNCs can selectively interact with liposomes or EVs through an attractive electrostatic interaction as demonstrated by zetametry and fluorescence microscopy. According to the ratio of nanoclusters to vesicles, the lipidic membranes can be fluorescently labeled without altering their thickness until charge reversion, the AuNCs being located at the level of the phosphate headgroups. In presence of an excess of AuNCs, the vesicles tend to adhere and …
American Chemical Society
Publication date: 
25 Jul 2022

Regina M Chiechio, Solene Ducarre, Grégory Moulin, Aurelien Dupont, Célia Marets, Pascale Even-Hernandez, Franck Artzner, Paolo Musumeci, Giorgia Franzò, Célia Ravel, Maria José LoFaro, Valérie Marchi

Biblio References: 
Volume: 13 Issue: 30 Pages: 6935-6943
The Journal of Physical Chemistry Letters