In this paper, Superconducting QUantum Interference Devices (SQUIDs) based on single layer Nb nanobridge Josephson junctions are described. Devices, with loop area ranging from 4 to 0.5 μm2, have been patterned by Electron Beam Lithography (EBL) in a 20 nm thick Nb layer, achieving a responsivity of about 30 μA/Φ0. Magnetization measurements have been performed via switching current measurements at a temperature T = 4.2 K. Preliminary detection of Silica-magnetite (Fe3O4–SiO2) core/shell nanoparticle cluster has been proven.