-A A +A
Type: 
Journal
Description: 
An economical nanoarray method to electrically detect hybridization events is demonstrated. As a proof of concept, we fabricated a sensor for DNA sequencing, in which targets are oligonucleotides conjugated to gold nanoparticles. As a consequence of target–probe binding events, a conductive bridge forms between two electrodes, resulting in a quantized change in conductivity. This enables a robust detection of a few (down to single) hybridization events and can be potentially applied also to other binding events (like specific interactions between proteins, antibodies, ligands and receptors). Moreover, target amplification techniques (such as PCR) are no longer necessary.
Publisher: 
Royal Society of Chemistry
Publication date: 
1 Jan 2009
Authors: 

Giuseppe Maruccio, Elisabetta Primiceri, Pasquale Marzo, Valentina Arima, Antonio Della Torre, Ross Rinaldi, Teresa Pellegrino, Roman Krahne, Roberto Cingolani

Biblio References: 
Volume: 134 Issue: 12 Pages: 2458-2461
Origin: 
Analyst