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Manipulating the anisotropy in 2D nanosheets is a promising way to tune or trigger functional properties at the nanoscale. Here Christian Martella et al. propose a novel approach  to introduce a one-directional anisotropy in MoS2 nanosheets via chemical vapor deposition onto rippled patterns prepared on ion-sputtered SiO2/Si substrates therein bringing evidences of morphology-dependent strain localization and charge doping. For more details, see C. Martella et al. Advanced Materials (2017), doi:10.1002/adma.201605785. More information on the research topic can be found on the Alessandro Molle's IMM webpage