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Three fluorenone-derived two-photon fluorescent probes (TK) targeting the lysosomes (TK-Lyso) and mitochondria (TK-Mito1 and TK-Mito2) were synthesized by introducing different diphenylamine moieties into the fluorenone core. The TK dyes showed high biocompatibility and long-term retention, low cytotoxicity, large Stokes shift and good fluorescence quantum yield. The results of the present work disclose a class of organic dyes with potential wide applications as specific and efficient probes for lysosomes and mitochondria in the study of various biological processes.
Royal Society of Chemistry
Publication date: 
1 Jan 2015

AL Capodilupo, V Vergaro, E Fabiano, Milena De Giorgi, F Baldassarre, Antonio Cardone, A Maggiore, V Maiorano, D Sanvitto, G Gigli, G Ciccarella

Biblio References: 
Volume: 3 Issue: 16 Pages: 3315-3323
Journal of Materials Chemistry B