Chiral materials showing Kramers-Weyl fermions represent a suitable platform for quantum technology, i.e., for engineering quantum solenoids, spin-torque devices, polarization-sensitive photodetectors based on quantized circular photogalvanic effect, etc. Accordingly, the stability of this class of materials in oxidative environments, such as the ambient atmosphere, should be carefully investigated to succeed in technology transfer. Here, taking as case-study example the well-recognized topological chiral system cadmium diarsenide (CdAs2), we assess its chemical reactivity towards ambient gases (oxygen and water) and air by density functional theory and experiments. The surface of CdAs2 evolves into an oxide skin, but its thickness remains nanometric even after one year in air, as directly imaged by high-resolution transmission electron microscopy. Accordingly, it is evident that future quantum devices based …